Published Time: Fri, 30 Jan 2026 14:07:40 GMT
UniProtKB/Swiss-Prot protein
Short name KKCC2_RAT
Length 587 amino acids
Species Rattus norvegicus (Rat)
Proteome UP000002494
Gene Camkk2
Function Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1 and CAMK4. Phosphorylates CAMK1D (By similarity). Seems to be involved in hippoca... Show More
Family membership None predicted
Isoforms
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Summary Full AlphaFold Confidence pLDDT
Representative families
PANTHER: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED
Representative domains
TED domains
Kinase-like_dom_sf - Protein kinase-like domain superfamily
SSF: Protein kinase-like (PK-like)
CATHGENE3D: Phosphorylase Kinase; domain 1
CDD: STKc_CaMKK2 - Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2
Prot_kinase_dom - Protein kinase domain
SMART: S_TKc - Serine/Threonine protein kinases, catalytic domain
PROFILE: PROTEIN_KINASE_DOM - Protein kinase domain profile
PFAM: Pkinase - Protein kinase domain
CATHGENE3D: Transferase(Phosphotransferase) domain 1
MobiDB-lite: Consensus Disorder Prediction
Polar Polyampholyte Proline-rich
cd14199
ATP binding site Activation loop (A-loop) Active site Polypeptide substrate binding site PIRSR BINDING: ATP BINDING: ATP. METAL: Magnesium; via carbonyl oxygen. BINDING: ATP. METAL: Magnesium. ACT_SITE: Proton acceptor BINDING: ATP CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) NP_BIND: ATP. ACT_SITE: Proton acceptor.
Ser/Thr_kinase_AS - Serine/threonine-protein kinase, active site
PROSITE: PROTEIN_KINASE_ST - Serine/Threonine protein kinases active-site signature
Protein_kinase_ATP_BS - Protein kinase, ATP binding site
PROSITE: PROTEIN_KINASE_ATP - Protein kinases ATP-binding region signature
Calcium/calmodulin-dependent protein kinase kinase
Calcium/calmodulin-dependent protein kinase kinase 2 isoform 1
biological process
molecular function
cellular component
PTHR43895:SF39
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