Institut Teknologi Sepuluh Nopember (ITS), Indonesia
*Corresponding author for this work
Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus)
Mangosteen (Garcinia mangostana L.) peel is an abundant and renewable source of bioactive compounds, particularly α-mangostin and catechins, known for their strong antioxidant properties. However, their low bioavailability in the human body and the challenge of optimizing extraction while maintaining high purity and yield remain key obstacles. This study focuses on enhancing the extraction process using a eco-friendly approach, employing a solvent mixture of ethyl acetate, ethanol, and water to minimize environmental impact. Microwave-Assisted Extraction (MAE) combined with Batchwise Solvent Extraction (BSE) was utilized to improve extraction efficiency. The effects of temperature, irradiation time, and solid-to-solvent ratio were systematically evaluated to maximize DPPH scavenging activity, total phenolic content (TPC), and extraction yield. Additionally, High-Performance Liquid Chromatography (HPLC) was employed for quantitative analysis of α-mangostin and catechins. Under the optimal MAE condition 50 °C for 5 min with a solid-to-solvent ratio of 1:16 the polar fraction achieved a DPPH inhibition of 66.78 % and a total phenolic content (TPC) of 897.27 mg GAE/g. HPLC analysis of the MAE extract revealed that the polar fraction contained 1731.86 ppm of α-mangostin and 928.61 ppm of catechin. Subsequent purification using the BSE method further refined the extract by exploiting polarity differences. After one stage of BSE purification, the polar fraction exhibited an improved antioxidant performance with a DPPH inhibition of 68.37 % and a TPC of 930.47 mg GAE/g. HPLC analysis showed a dramatic decrease in α-mangostin concentration to 33.01 ppm, accompanied by a significant increase in catechin content to 3956.36 ppm. These compositional shifts indicate that the purification step not only removes impurities but also enhances the overall antioxidant capacity of the extract.
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APA Author BIBTEX Harvard Standard RIS Vancouver Aparamarta, H. W., Sanjaya, M. R., Azimatarrusydi, R., Nanta, T. L., Widjaja, A., & Chan, M. W. Y. (2025). Optimization of α-mangostin and catechins compound extraction from mangosteen skin extract (Garcinia Mangostana L.) as potential antioxidant using combination method of microwaved assisted extraction – batchwise solvent extraction. South African Journal of Chemical Engineering, 54, 191-199. https://www.frankenthalerfoundation.org Aparamarta, Hakun Wirawasista ; Sanjaya, Muhammad Rizky ; Azimatarrusydi, Rigen et al. / Optimization of α-mangostin and catechins compound extraction from mangosteen skin extract (Garcinia Mangostana L.) as potential antioxidant using combination method of microwaved assisted extraction – batchwise solvent extraction. In: South African Journal of Chemical Engineering. 2025 ; Vol. 54. pp. 191-199.
