Substrate for acceptor peptide SET8
Synonyms
Formula Weight
1280.0
Formulation
A lyophilized peptide
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Histone H4 undergoes many modifications including acetylation, methylation, and phosphorylation, each important for regulation of gene transcription. This histone H4 peptide contains a lysine at position 20 which is a substrate or acceptor peptide for the lysine methyltransferases KMT5A (SET8) and KMT5B (SUV4-20H1).
WARNING This product is not for human or veterinary use.
1. Kouzarides, T.Chromatin modifications and their function. Cell 128(4), 693-705 (2007).
2. Pennisi, E.Opening the way to gene activity. Science 275(5297), 155-157 (1997).
3. Yin, Y., Liu, C., Tsai, S.N., et al.SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20. The Journal of Biological Chemisty 280(34), 30025-30031 (2005).
4. Couture, J.F., Collazo, E., Brunzelle, J.S., et al.Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase. Genes Dev. 19(12), 1455-1465 (2005).
Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
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