Synonym(s): m32
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Empirical Formula (Hill Notation): C 136 H 209 N 41 O 34
Molecular Weight: 2962.37
UNSPSC Code: 12352200
MDL number: MFCD00798702
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≥90%
P01303, P22466
−20°C
human ... GAL(51083), NPY(4852)
This chimeric peptide is a high affinity galanin receptor antagonist (IC 50=0.1 nM in rat hypothalamus membranes and Kd=0.01 nm in rat spinal cord membranes). This peptide is also recognized by neuropeptide Y receptors (IC 50=0.25 μM in rat cerebral cortex membranes) and is a Y 2 agonist in rat vas deferens.
11 - Combustible Solids
WGK 3
Not applicable
Eyeshields, Gloves, type N95 (US)
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Functional effects and ligand binding of chimeric galanin-neuropeptide Y (NPY) peptides on NPY and galanin receptor types. U Kahl et al. British journal of pharmacology, 111(4), 1129-1134 (1994-04-01) 1. The effects and binding characteristics of a series of chimeric galanin-neuropeptide Y (NPY) peptides were examined in various preparations known to contain a predominant population of either Y1 or Y2 receptors for NPY or galanin receptors. 2. NPY suppressed
Solution structure by 2D 1H-NMR of a chimeric peptide recognized by galanin and neuropeptide Y receptors. K Arvidsson et al. Biochemistry, 32(30), 7787-7798 (1993-08-03) The 25 amino acid residue chimeric peptide M32, galanin(1-13)-neuropeptide Y(25-36)-amide, was synthesized. The peptide was found to be recognized by both galanin and NPY receptors. The solution structure in 30% (v/v) 1,1,1,3,3,3-hexafluoro-2-propanol was examined by 2-D 1H-NMR and by CD.
New high affinity peptide antagonists to the spinal galanin receptor. X J Xu et al. British journal of pharmacology, 116(3), 2076-2080 (1995-10-01) 1. The role of endogenous galanin in somatosensory processing has been studied with galanin receptor antagonists. The new galanin receptor ligands C7, M32, M38 and M40 bind with high affinity (Kd in nanomolar range) to spinal cord galanin receptors and
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