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topical antiseptic function

Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema - Matterne, U - 2019 | Cochrane Library

Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema - Matterne, U - 2019 | Cochrane Library

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Contents

  • Abstract
  • PICOs
  • Plain language summary
  • Authors' conclusions
  • Summary of findings
  • Background
  • Objectives
  • Methods
  • Results
  • Discussion
  • Figures and tables
  • References
  • Supplementary materials
  • Search strategies
  • Characteristics of studies
  • Analyses
  • Download data
  • Related
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  • Editorials
  • Audio summaries
  • Special Collections
  • About this review
  • Information
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Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema

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References to studies included in this review

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Berth Jones 1989 {published data only}

Berth‐Jones J, Graham‐Brown RA. Failure of terfenadine in relieving the pruritus of atopic dermatitis. British Journal of Dermatology 1989;121(5):635‐7. [CENTRAL: CN‐00064362; PUBMED: 2574594] CENTRAL Link to article Google Scholar

Cambazard 2001 {unpublished data only}

Cambazard F, UCB Pharma. Efficacy and safety of cetirizine drops at 3 doses (0.25, 0.50, 0.75 mg/kg bw/day) in an 8‐week treatment of atopic dermatitis in 1 to 5 year old children: a multicentric, multi‐country, double‐blind, placebo‐controlled, randomised study, 2001. art45‐paediatric‐studies‐docs.ema.europa.eu/GROUP%20C/UCB_Cetirizine/Clinical%20Study%20Reports%20‐%20Cetirizine%20(part%203)/9708%20‐%20Cetirizine%20‐%20MRCE00H0202.pdf (accessed 26 April 2017). CENTRAL

Diepgen 2002 {published data only}

Businco L. Early treatment of the atopic child: first results of the clinical trial. Pediatric Pulmonology. Supplement 1997;23(S16):73. [CENTRAL: CN‐00147078; PUBMED: 9443210] CENTRAL Link to article Google Scholar Diepgen T. Impact of cetirizine on atopic dermatitis. Journal of the European Academy of Dermatology and Venereology 1999;12(Suppl 2):S133. [CENTRAL: CN‐00478509] CENTRAL Google Scholar Diepgen TL, Early Treatment of the Atopic Child Study Group. Long‐term treatment with cetirizine of infants with atopic dermatitis: a multi‐country, double‐blind, randomized, placebo‐controlled trial (the ETAC trial) over 18 months. Pediatric Allergy and Immunology 2002;13(4):278‐86. [CENTRAL: CN‐00434564; PUBMED: 12390444] CENTRAL Link to article PubMed Google Scholar Estelle F, Simons R. Prospective, long‐term safety evaluation of the H1‐receptor antagonist cetirizine in very young children with atopic dermatitis. Allergologie 2000;23(5):244‐55. [CENTRAL: CN‐00424063] CENTRAL Google Scholar Simons FER, ETAC Study Group on Early Treatment of the Atopic Child. Prospective, long‐term safety evaluation of the H1‐receptor antagonist cetirizine in very young children with atopic dermatitis. Journal of Allergy and Clinical Immunology 1999;104(2 Pt 1):433‐40. [CENTRAL: CN‐00414410; PUBMED: 10452767] CENTRAL Link to article Google Scholar Stevenson J, Cornah D, Evrard P, Vanderheyden V, Billard C, Bax M, et al. Long‐term evaluation of the impact of the H1‐receptor antagonist cetirizine on the behavioral, cognitive, and psychomotor development of very young children with atopic dermatitis. Pediatric Research 2002;52(2):251‐7. [CENTRAL: CN‐00409300; PUBMED: 12149503] CENTRAL Link to article PubMed Google Scholar

Doherty 1989 {published data only}

Doherty V, Sylvester DG, Kennedy CT, Harvey SG, Calthrop JG, Gibson JR. Treatment of itching in atopic eczema with antihistamines with a low sedative profile. BMJ 1989;298(6666):96. [CENTRAL: CN‐00058292; PUBMED: 2563952] CENTRAL Link to article PubMed Google Scholar

Falk 1993 {published data only}

Falk ES. Ketotifen in the treatment of atopic dermatitis. Results of a double blind study. European Review for Medical and Pharmacological Sciences 1993;15(2):63‐6. [CENTRAL: CN‐00100944; PUBMED: 8171216] CENTRAL PubMed Google Scholar

Frosch 1984 {published data only}

Frosch PJ, Schwanitz HJ, Macher E. A double blind trial of H1 and H2 receptor antagonists in the treatment of atopic dermatitis. Archives of Dermatological Research 1984;276(1):36‐40. [CENTRAL: CN‐00033953; PUBMED: 6142700] CENTRAL Link to article PubMed Google Scholar Schwanitz HJ, Frosch PJ, Macher E. Results of a double blind study with H1‐ and H2‐histaminereceptor antagonists in atopic dermatitis. Archives of Dermatological Research 1992;273(1‐2):164. [CENTRAL: CN‐00350456] CENTRAL Google Scholar

Hannuksela 1993 {published data only}

Hannuksela M, Kalimo K, Lammintausta K, Mattila T, Turjanmaa K, Varjonen E, et al. Dose ranging study: cetirizine in the treatment of atopic dermatitis in adults. Annals of Allergy 1993;70(2):127‐33. [CENTRAL: CN‐00090744; PUBMED: 8430920] CENTRAL PubMed Google Scholar

Henz 1998 {published data only}

Henz BM, Metzenauer P, O'Keefe E, Zuberbier T. Differential effects of new‐generation H1‐receptor antagonists in pruritic dermatoses. Allergy 1998;53(2):180‐3. [CENTRAL: CN‐00684205; PUBMED: 9534917] CENTRAL Link to article PubMed Google Scholar

Hjorth 1988 {published data only}

Hjorth N. Terfenadine in the treatment of chronic idiopathic urticaria and atopic dermatitis. Cutis; Cutaneous Medicine for the Practitioner 1988;42(4A):29‐30. [CENTRAL: CN‐00268216; PUBMED: 2903817] CENTRAL Google Scholar

Iikura 1992 {published data only}

Iikura Y, Baba M, Mikawa H, Nishima S, Maeda K, Akasaka T, et al. A double blind study of the effectiveness of ketotifen in preventing the development of asthma in atopic dermatitis patients. Arerugi [Allergy] 1991;40(2):132‐40. [CENTRAL: CN‐00487852; PUBMED: 2069512] CENTRAL PubMed Google Scholar Iikura Y, Naspitz CK, Mikawa H, Talaricoficho S, Baba M, Sole D, et al. Prevention of asthma by ketotifen in infants with atopic dermatitis. Annals of Allergy 1992;68(3):233‐6. [CENTRAL: CN‐00082427; PUBMED: 1546818] CENTRAL PubMed Google Scholar

Jung 1989 {unpublished data only}

Jung EG, Kaymer FG, Ring J, Casimir G, de Bersaques J, de la Brassine M, et al. Multicentre double‐blind study in parallel groups, comparing to placebo 5 and 10 mg cetirizine administered in two daily doses for a week, to children aged 3 – 6 years suffering from atopic dermatitis – determination of the antipruritic effect. UCB Pharmaceutical Sector, 1989. http://art45‐paediatric‐studies‐docs.ema.europa.eu/GROUP%20C/UCB_Cetirizine/Clinical%20Study%20Reports%20‐%20Cetirizine%20(part%203)/A103%20‐%20Cetirizine%20‐%20CE89G241.pdf (accessed 26 April 2017). CENTRAL

Kawashima 2003 {published data only}

Kawashima M, Nakagawa H, Tango T, Harada S. Fexofenadine is effective at reducing itching associated with atopic dermatitis. Journal of Allergy, Asthma and Immunolgy 2002;109(Suppl 1):S160‐1. CENTRAL Link to article Google Scholar Kawashima M, Nakagawa H, Tango T, Harada S, Noguchi T, Inagi M. Fexofenadine is effective at reducing itching associated with atopic dermatitis. Annales de Dermatologie et de Venereologie 2002;129(Suppl 1 Pt 2):1S413. [CENTRAL: CN‐00454385] CENTRAL Link to article Google Scholar Kawashima M, Tango T, Noguchi T, Inagi M, Nakagawa H, Harada S. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1‐week randomized, multicentre, double‐blind, placebo‐controlled, parallel‐group study. British Journal of Dermatology 2003;148(6):1212‐21. [CENTRAL: CN‐00438764; PUBMED: 12828751] CENTRAL Link to article Google Scholar

Kimura 2009 {published data only}

Kimura U, Matsuba S, Chikenji T, Haruna K, Kamano M, Suga Y, et al. Usefulness of TARC in serum as treatment marker and combination treatment with loratadine and steroid ointment for atopic dermatitis. Skin Research 2009;8(2):125‐31. [CENTRAL: CN‐00802955] CENTRAL Google Scholar

Kircik 2013 {published and unpublished data}

Kircik L. Management of pruritus with Xyzal in atopic dermatitis, 2013. https://www.frankenthalerfoundation.org§=X70156. CENTRAL Kircik L. Management of pruritus with levocetirizine dihydrochloride in atopic dermatitis in a randomized, double‐blind, placebo controlled study ‐ Interim analysis of 21 subjects. Allergy and Asthma Proceedings 2010;31(2):166. [CENTRAL: CN‐00980752] CENTRAL Google Scholar

Kuniyuki 2009 {published data only}

Kuniyuki S, Yoshida Y, Maekawa N, Yamanaka K. Examination of olopatadine hydrochloride for anti‐itching and topical‐steroid sparing effects in patients with chronic eczema or dermatitis. Nishinihon Journal of Dermatology 2009;71(5):526‐30. [CENTRAL: CN‐00754437; DOI: 10.2336/nishinihonhifu.71.526] CENTRAL Link to article Google Scholar

Langeland 1994 {published data only}

Langeland T, Fagertun HE, Larsen S. Therapeutic effect of loratadine on pruritus in patients with atopic dermatitis. A multi‐crossover‐designed study. Allergy 1994;49(1):22‐6. [CENTRAL: CN‐00101711; PUBMED: 8198236] CENTRAL Link to article PubMed Google Scholar

LaRosa 1994 {published data only}

La Rosa M, Ranno C, Musarra I, Guglielmo F, Corrias A, Bellanti JA. Double‐blind study of cetirizine in atopic eczema in children. Annals of Allergy 1994;73(2):117‐22. [CENTRAL: CN‐00103861; PUBMED: 8067594] CENTRAL PubMed Google Scholar

Leon 1989 {published data only}

Leon G, Arellano I. Tolerance and efficacy of ketotifen in children with atopic dermatitis [Tolerancia y eficacia del ketotifeno en ninos con dermatitis atopica]. Dermatologia Revista Mexicana 1989;33(3):153‐60. [CENTRAL: CN‐00510646] CENTRAL Google Scholar

Monroe 1992 {published data only}

Monroe EW. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis. Clinical Therapeutics 1992;14(1):17‐21. [CENTRAL: CN‐00083752; PUBMED: 1349509] CENTRAL PubMed Google Scholar

Munday 2002 {published data only}

Munday J, Bloomfield R, Goldman M, Robey H, Kitowska GJ, Gwiezdziski Z, et al. Chlorpheniramine is no more effective than placebo in relieving the symptoms of childhood atopic dermatitis with a nocturnal itching and scratching component. Dermatology (Basel, Switzerland) 2002;205(1):40‐5. [CENTRAL: CN‐00397742; PUBMED: 12145433] CENTRAL Link to article PubMed Google Scholar

Nuovo 1992 {published data only}

Nuovo J, Ellsworth AJ, Larson EB. Treatment of atopic dermatitis with antihistamines: lessons from a single‐patient, randomized clinical trial. Journal of the American Board of Family Practice 1992;5(2):137‐41. [CENTRAL: CN‐00083686; PUBMED: 1575065] CENTRAL Google Scholar

Ruzicka 1998 {published data only}

Ruzicka T, Karmann B, Kowok K, Altmeyer P. Atopisches ekzem: behandlung mit loratadin. Der Deutsche Dermatologe 1998;46(4):1‐8. CENTRAL Google Scholar

Savin 1986 {published data only}

Savin JA, Dow R, Harlow BJ, Massey H, Yee KF. The effect of a new non‐sedative Hsub 1‐receptor antagonist (LN2974) on the itching and scratching of patients with atopic eczema. Clinical and Experimental Dermatology 1986;11(6):600‐2. [CENTRAL: CN‐00240981; PUBMED: 2889550] CENTRAL Link to article Google Scholar

Simons 2007 {published data only}

Simons FE, Early Prevention of Asthma in Atopic Children (EPAAC) Study Group. Safety of levocetirizine treatment in young atopic children: an 18‐month study. Pediatric Allergy and Immunology 2007;18(6):535‐42. [CENTRAL: CN‐00610098; PUBMED: 17561929] CENTRAL Link to article PubMed Google Scholar Simons FE, Early Prevention of Asthma in Atopic Children Study Group. H1‐antihistamine treatment in young atopic children: effect on urticaria. Annals of Allergy, Asthma & Immunology 2007;99(3):261‐6. [CENTRAL: CN‐00612359; PUBMED: 17910330] CENTRAL Link to article Google Scholar

Tharp 1998 {published data only}

Tharp MD, Lowe NJ, Soter N, Kramer B. A double blind parallel study of cetirizine C 20 mg and placebo P in the management of patients with atopic dermatitis AD. Annals of Allergy, Asthma and Immunology 1998;80:110. [CENTRAL: CN‐00285014] CENTRAL Google Scholar

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