Trp7 beta-Ala8 Neurokinin A

Neurokinin A (porcine) | CAS 86933-74-6 | NKA

acetyl tetrapeptide 22 cas no 1295648 76 8 powder macro

Neurokinin A (porcine)

Cat. No. 1152. Discontinued Product. 1152 has been discontinued.

Description

Endogenous tachykinin peptide. Alternative Names: NKA.

Biological Activity

Endogenous tachykinin peptide; more potent bronchoconstrictor than Substance P.

Technical Data

Property	Value
M. Wt	1133.3
Formula	C50 H80 N14 O14 S
Sequence	HKTDSFVGLM (Modifications: Met-10 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	86933-74-6
PubChem ID	5311311
InChI Key	HEAUFJZALFKPBA-JPQUDPSNSA-N
Smiles	[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Lippe et al (1997) Neurokinin A-induced vasoconstriction and muscular contraction in the rat isolated stomach: mediation by distinct and unusual neurokinin A 2 receptors. J.Pharmacol.Exp.Ther. 281 1294 PMID:9190865
Nawa et al (1983) Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor. Nature 306 32 PMID:6195531
Sherwood et al (1997) Bronchoconstrictor and respiratory effects of neurokinin A in dogs. J.Pharmacol.Exp.Ther. 283 788 PMID:9353399

Citations

Citations are publications that use Tocris products. Selected citations for Neurokinin A (porcine) include:

Gutierrez and Boada (2019) Neuropeptide-induced modulation of carcinogenesis in a metastatic breast cancer cell line (MDA-MB-231LUC+). Cancer Cell Int 18 216 PMID:30598641

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