urodilatin analog

Urodilatin (human) | 118812-69-4

CAS No.118812-69-4 Chemical Name:Urodilatin (human)Synonyms L-Tyrosine, L-threonyl-L-alanyl-L-prolyl-L-arginyl-L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanylglycylglycyl-L-arginyl-L-methionyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenyla...CBNumber:CB33051053 Molecular Formula:C145H234N52O44S3 Molecular Weight:3505.97 MDL Number:MOL File:118812-69-4.mol

Last updated:2025-07-04 15:28:44

Urodilatin (human) Properties

Urodilatin (human) Chemical Properties,Uses,Production

Uses

Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure.

in vivo

Ularitide (10nmol/kg, s.c., once) increases in urine volume and sodium excretion in arteriovenous (AV) fistula dogs.

Animal Model:Female dogs with or without surgically induced chronic aortocaval fistula Dosage:5 and 10 pmol/kg/min Administration:i.v. infusions for for 75 min, and thereafter at 10 pmol/kg/min for another 75 min. Result:Increased in urine volume and sodium excretion with high-output CHF.

References

• Anker SD, et al. Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies. Eur Heart J. 2015 Mar 21;36(12):715-23.
• Korn C, et al. Comparison of the effects of ularitide acetate and other bronchorelaxing substances on the thrombin-induced permeability raise of human endothelial cell monolayers. Arzneimittelforschung. 1998 Mar;48(3):251-8. PMID:9553682
• Nally JE, et al. Bronchodilator and pre-protective effects of urodilatin in bovine bronchi in vitro: comparison with atrial natriuretic peptide. Br J Pharmacol. 1995 Apr;114(7):1391-6.
• Valentin JP, et al. Urodilatin binds to and activates renal receptors for atrial natriuretic peptide. Hypertension. 1993 Apr;21(4):432-8.
• Choi MR, et al. Urodilatin regulates renal dopamine metabolism. J Nephrol. 2013 Nov-Dec;26(6):1042-8.

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L-Tyrosine, L-threonyl-L-alanyl-L-prolyl-L-arginyl-L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanylglycylglycyl-L-arginyl-L-methionyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenyla...118812-69-4

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