Vasodilation peptide

Vasodilator peptide 1095.6 Da

Not For Human Use, Lab Use Only.

Product Information

Product Name Vasodilator peptide 1095.6 Da

• Sequence Shortening pGlu-GRPPGPPIPP
• Sequence pGlu-Gly-Arg-Pro-Pro-Gly-Pro-Pro-Ile-Pro-Pro
• Length (aa)11
• Peptide Purity (HPLC)95.65%
• Molecular Weight 1095.27
• Source Synthetic
• Form Powder
• Description Vasodilator peptide 1095.6 Da is a low molecular mass peptide identified in the crude venom of Bothrops jararacussu. It belongs to the family of bradykinin-potentiating peptides (BPPs), characterized by a pyroglutamic acid residue at the N-terminus and a C-terminal Ile-Pro-Pro (IPP) motif. The peptide has a measured mass of 1095.66 Da ([M+H]+) and its determined amino acid sequence is ZGRPPGPPIPP, where Z represents pyroglutamic acid. This proline-rich peptide was detected via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) analysis of the unfractionated venom. Its identification was confirmed by tandem mass spectrometry (MS/MS) de novo sequencing. The peptide is one of several novel BPPs reported in the study, highlighting the diversity of such components in snake venoms.
• Storage Guidelines Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C.

References

• Wermelinger LS, Dutra DL, Oliveira-carvalho AL, Soares MR, Bloch C, Zingali RB. Fast analysis of low molecular mass compounds present in snake venom: identification of ten new pyroglutamate-containing peptides. Rapid Commun Mass Spectrom. 2005;19(12):1703-8.

About TFA salt

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

Related Products / Services

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2 H, 15 N, and 13 C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"