Dear friends,
Some 4,5 doubly substituted tryptamines can be toxic. See the info in the attachment below.
This means that in general, care should be taken when adding 5-substituted tryptamines such as 5-HTP, bufotenine, 5-MEO-DMT, and melatonin to a mushroom substrate. This is because if the mushrooms succeed in modifying the 4-position (like they naturally do when producing psiloc(yb)in) they could produce a 4,5 substituted tryptamine.
While the possible products won't be as toxic as 5,7-Dihydroxytryptamine, and the mushroom may not succeed in modifying the 4-position if the 5-position is occupied (does anyone know?), the potential for toxicity does exist until more information is presented.
If someone has more information on the possible toxicity and/or the ability of the mushroom to substitute the 4-position when the 5-position is already substituted please chime in. I for one, am not going to do any bioassays of fruits from substrates with 5-substituted tryptamines until someone can clarify the situation further.
So for now, I'm keeping the ground yopo seeds and 5-HTP away from the monotub. Thank you.
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Shit.
My outdoor cyanescens bed has just started fruiting for the first time.
About six months ago I scattered some out-of-date chacruna leaves over the top of it, just as a means of getting rid of them and returning their power to the system.
Should I worry? It was just a couple of loose handfuls over maybe a meter square.
I've not eaten any yet. I'm bummed, but also I don't want to fuck up my neurons.
Please tell me everything will be okay?!?
That should be perfectly fine. The only potential issue I'm bringing up is feeding mushrooms fresh relatively strong (in the order of .01M) 5-OH substituted triptamines (bufotenine/yopo and 5-HTP).
Again, this issue is just a potential warning. The mushroom would need to be able to add it's 4-OH group with the 5-OH group already present, and we don't know yet if it is even possible, only that it could happen. Even if it happened the 4,5-OH substituted toxicity is lower than other double substituted -OH triptamines. One way only get a bad head ache, I don't really know.
Until we know more I would not add yopo seeds or 5-HTP supplements in mushroom grows. That's all I wanted to bring up since there has been some activity around general mushroom substituted triptamine doping (mexamine, melatonin, triptamine, etc).
Thank you, I’ll proceed with great caution.
The caution due with P. cyanescens is, even in your case, down to their fairly hefty potency, especially when fresh (psilocin).
They also happen to taste very good in a miso soup, which covers up their yeasty odour nicely. The wisdom of making potent psychoactive soup more than barely palatable is, of course, highly questionable
At least you have no grounds for concern about polyhydroxylated tryptamines (in my non-expert opinion).
