By Kiana Murden and Jenny Berg
February 25, 2026
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I’m holding off on Botox for now, and I am quite the holdout. At 45 years old, I’m the last one of my friends or coworkers to give the neuromodulator a shot (pun intended), and many women get “preventative Botox” in their 20s. I’m not morally opposed to Botox, don’t get me wrong; it’s just that I’m not as committed as I could be to keeping regular appointments. Luckily, I do have a stash of the best Botox-in-a-Bottle skincare products to keep my skin in relatively youthful shape. (Perhaps not in-my-20s-with-Botox shape, but you get the drift.)
“Botox in a bottle refers to the growing category of products designed to either serve as an alternative to Botox or help extend the longevity of Botox treatments,” says Jeffrey Lee, MD a double board-certified plastic surgeon and the founder of JL Plastic Surgery in Boston. “Botox itself remains an extremely powerful, effective, and reliable treatment. The main drawbacks are that it requires an in-office visit every three to four months and can be costly.” As a result, he says, brands are competing to develop the best topical products that can be used to mimic the effects of Botox at home—to the degree that topical products can—and prolong the effects of regular injections.
SkinCeuticals P-TIOX
$150 BLUEMERCURY
The Ordinary Argireline Solution 10% for Fine Lines
$10 NORDSTROM
