Helen Frankenthaler Foundation

Cell-permeable PKC inhibitor peptide

PKC b pseudosubstrate | CAS 172308-76-8

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PKC b pseudosubstrate | CAS 172308-76-8 | Tocris Bioscience

Cat. No. 1792

Discontinued Product

1792 has been discontinued.

Description

Selective cell-permeable PKC inhibitor peptide (attached to vector)

Alternative Names: Protein kinase C beta pseudosubstrate

Biological Activity

PKC β pseudosubstrate is a selective cell-permeable peptide inhibitor of protein kinase C (IC 50 ~ 0.5 μ M). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.

Technical Data

PropertyValue
M. Wt3994.84
FormulaC 177 H 294 N 62 O 38 S 3
SequenceCRQIKIWFQNRRMKWKK CRFARKGALRQKNV* (Modifications: Disulfide bridge between 17 -1*)
StorageStore at -20°C
CAS Number172308-76-8
PubChem ID90488712
InChI KeyKIWJPYSSLFMLBZ-OSCDWKIESA-N
Smiles[HN][C@@H](CSSC[C@H]([NH])C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

  • Certificate of Analysis / Product Datasheet
  • Safety Datasheet

References

References are publications that support the biological activity of the product.

  • Derossi et al (1994) The third helix of the antennapedia homeodomain translocates through biological membranes. J.Biol.Chem. 269 10444 PMID:8144628
  • House and Kemp (1987) Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238 1726 PMID:3686012
  • Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158 PMID:7472470
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