α-Conotoxin IMI supplier

Alpha-conotoxin PrXA - Conus parius (Cone snail) | UniProtKB | UniProt

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P0C8S5 · CCAA_CONPI

• Protein Alpha-conotoxin PrXA
• Status UniProtKB reviewed (Swiss-Prot)
• Organism Conus parius (Cone snail)
• Amino acids 85 (go to sequence)
• Protein existence Evidence at protein level
• Annotation score 4/5

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Function

function

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits both adult and fetal (alpha-1/beta-1/epsilon/delta and alpha-1/beta-1/gamma/delta subunits) mammalian muscle nicotinic acetylcholine receptors (nAChR). In vivo, it causes paralysis and death in mice and fish.1 publication

Gene Ontology

GO annotations

GO-CAM models New

Gene Ontology (GO) annotations organized by slimming set.

Access the complete set of GO annotations on QuickGO

Keywords

• Molecular function
  • #Acetylcholine receptor inhibiting toxin
  • #Ion channel impairing toxin
  • #Neurotoxin
  • #Postsynaptic neurotoxin
  • #Toxin

Protein family/group databases

• TCDB
  • 8.B.36.1.2the contulakin lt (contulakin lt) family

Names & Taxonomy

Protein names

• Recommended name Alpha-conotoxin PrXA Curated
• Short name Alpha-C-PrXA 1 publication

Organism names

• Taxonomic identifier 505247(NCBI)
• Organism Conus parius (Cone snail)
• Taxonomic lineage cellular organisms>Eukaryota (eukaryotes)>Opisthokonta>Metazoa (animals)>Eumetazoa>Bilateria>Protostomia>Spiralia>Lophotrochozoa>Mollusca (molluscs)>Gastropoda (gastropods)>Caenogastropoda>Neogastropoda>Conoidea>Conidae (Cone snails)>Conus>Phasmoconus

Accessions

• Primary accession P0C8S5
• Secondary accessions
  • E2DEK9

Organism-specific databases

• ConoServer
  • 2859PrXA

Subcellular Location

UniProt Annotation

GO Annotation

Secreted1 publication

• extracellular regionSource:UniProtKB-SubCell
• host cell postsynaptic membraneSource:UniProtKB-KW

Complete GO annotation on QuickGO

Keywords

• Cellular component
  • #Secreted

Expression

Tissue specificity

Expressed by the venom duct.1 publication

Structure

3D structure databases

• AlphaFoldDB
  • P0C8S5
• ModBase
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• SWISS-MODEL-Workspace
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Family & Domains

Domain

The cysteine framework is C-C.Curated

Keywords

• Domain
  • #Signal

Family and domain databases

• MobiDB
  • Search…

Sequence

• Sequence status Complete
• Sequence processing The displayed sequence is further processed into a mature form.

See also sequence in UniParc or sequence clusters in UniRef

• Length 85
• Mass (Da) 9,492
• Last updated 2018-05-23 v2
• MD5 Checksum 5BA5E95DA3A213882218F5A4B0E9E7AA

MQTAYWVMVMMMVMWITAPLSEGGKPKLIIRGLVPNDLTPQRILRSLISGRTYGIYDAKPPFSCAGLRGGCVLPPNLRPKFKEGR

Mass Spectrometry

Molecular mass is 3,540.7 Da. Determined by MALDI. 1 publication

Keywords

• Technical term
  • #Direct protein sequencing

Sequence databases

Similar Proteins

UniRef clusters

Orthologs & paralogs

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Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.

Release 2026_01 | Statistics

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