Dermal matrix repair

MatriDerm® Dermal Skin Matrix

MatriDerm® is a unique collagen-elastin-template, which serves as a dermal replacement scaffold and can be applied both in a Single and Multi-Stage Procedure.

Native collagen fibers

• Guided healing to avoid unstructured scar tissue[[8,10,11]]
• Improved cell migration and reconstruction of new dermis scaffold.[[10-11]]

Elastin

• Triggers early vascularization[[3,4,5,19]] and may reduce risk of infection (revascularization allows for white blood cells to migrate to the site)[[18,19]]
• Significantly improves skin elasticity (compared to split-thickness skin graft alone)[[1,5,6,7,9]]
• Enables early physical therapy and rehabilitation[[20]]

No chemical cross-linking

• Non-release of cell-toxic substances
• Improved cellular growth[[12,13]]

8. Scanning-Electron-Microscopy-images: © Dr. M. Mörgelin, University Lund, Sweden.

10. de Vries H et al. Wound Repair Regen. 1994;2(1):37-47.

11. de Vries H et al. Br J Dermatol. 1995;132(5):690-7.

10. de Vries H et al. Wound Repair Regen. 1994;2(1):37-47.

11. de Vries H et al. Br J Dermatol. 1995;132(5):690-7.

3. Geyer et al. Annals of Anatomy. 2015;197:3-10.

4. Wiedner M et al. Wound Repair Regen. 2014;22(6):749-54.

5. Daamen WF et al. Tissue Eng. 2008;14(3):349-60.

19. Frueh FS et al. J Invest Dermatol. 2017;137:217-27.

18. Granick MS, Teot L. Informs Healthcare. 2nd ed. CRC Press; 2012.

19. Frueh FS et al. J Invest Dermatol. 2017;137:217-27.

1. Bloemen MO et al. Plast Reconstr Surg. 2010;125(5):1450-9.

5. Daamen WF et al. Tissue Eng. 2008;14(3):349-60.

6. Haslik W et al. JPRAS. 2010;63(2):360-4.

7. Ryssel H et al. Burns. 2008;34(1):93-7.

9. Ryssel H et al. Int Wound J. 2010;7(5):385-92.

20. Haslik et al. Burns. 2007;33(3):364-8.

12. Killat J et al. Int J Mol Sci. 2013;14(7):14460-74.

13. Wietbrook JO. Dissertation. Ludwig-Maximilians-Universität München; 2016.

The mode of action

In a One- or Multi-Step Procedure, MatriDerm® is placed on the wound bed and covered with a split-thickness skin graft or a non-adherent layer plus secondary dressing of choice.

MatriDerm® provides a native three-dimensional collagen elastin matrix to facilitate cell migration and guided healing.[[8,10,11]]

Fibroblasts are guided by the native collagen elastin scaffold ensuring structured healing and formation of a neo-dermis.[[8,10,11]]

Enhanced neo-angiogenesis and formation of microvessels ensuring supply and optimal split-thickness skin graft take.[[1,5,6,7,9,14]]

1. Bloemen MO et al. Plast Reconstr Surg. 2010;125(5):1450-9.

5. Daamen WF et al. Tissue Eng. 2008;14(3):349-60.

6. Haslik W et al. JPRAS. 2010;63(2):360-4.

7. Ryssel H et al. Burns. 2008;34(1):93-7.

9. Ryssel H et al. Int Wound J. 2010;7(5):385-92.

14. Cervelli V et al. Int Wound J. 2011;8(4):400-5.

The scientific difference

MatriDerm® is able to preserve closeness to human dermis, accelerate cell invasion, cell elongation and proliferation and limit myofibroblast formation which is associated with less wound contraction. [[2,4,10,11,12,21,22,23]]This scientific performance is as a result of our Advanced CryoSafe® Method which gently preserves the native structure with no chemical crosslinking.[[2]]

2. Böhm S et al. Materials. 2017;10(9):1086.

4. Wiedner M et al. Wound Repair Regen. 2014;22(6):749-54.

10. de Vries H et al. Wound Repair Regen. 1994;2(1):37-47.

11. de Vries H et al. Br J Dermatol. 1995;132(5):690-7.

12. Killat J et al. Int J Mol Sci. 2013;14(7):14460-74.

21. Dill V, Moergelin M. Int Wound J. 2020;17(3):618-30.

22. Kattan WM et al. J Coll Physicians Surg Pak. 2017;27:38-43.

23. Schmidt VJ et al. Ann Plast Surg. 2017;79(1):92-100.

2. Böhm S et al. Materials. 2017;10(9):1086.

Preserves

MatriDerm® preserves closeness to human dermis.[[8,21]]

MatriDerm® has similar ultrastructural features as native collagen fibre bundles in human dermis. The other processed dermal matrices show large fields with amorphous structures.

8. Scanning-Electron-Microscopy-images: © Dr. M. Mörgelin, University Lund, Sweden.

21. Dill V, Moergelin M. Int Wound J. 2020;17(3):618-30.

Accelerates

In an animal AV-Loop model number of new formed blood vessels were analyzed in wounds treated with either with MatriDerm® or competitor product. MatriDerm® accelerates revascularization.[[23]]

23. Schmidt VJ et al. Ann Plast Surg. 2017;79(1):92-100.

Limits

In vitro analysis of the formation of myofibroblast phenotype by α-SMA staining. MatriDerm® limits myofibroblast formation compared to competitor products. Myofibroblast formation is associated with wound contraction. By limiting myofibroblast formation wound contraction is limited