Digestive Health Ingredients

Proteins and Peptides from Food Sources with Effect on Satiety and Their Role as Anti-Obesity Agents: A Narrative Review

Ignot-Gutiérrez, Anaís; Serena-Romero, Gloricel; Guajardo-Flores, Daniel; Alvarado-Olivarez, Mayvi; Martínez, Armando J; Cruz-Huerta, Elvia.

Affiliation

• Ignot-Gutiérrez A; Instituto de Neuroetología, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s/n, Industrial Ánimas, Xalapa 91193, Veracruz, Mexico.
• Serena-Romero G; Centro de Investigaciones Biomédicas, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s/n, Industrial Ánimas, Xalapa 91193, Veracruz, Mexico.
• Guajardo-Flores D; Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Centro de Biotecnología FEMSA, Eugenio Garza Sada 2501 Sur, Monterrey 64849, Nuevo León, Mexico.
• Alvarado-Olivarez M; Instituto de Neuroetología, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s/n, Industrial Ánimas, Xalapa 91193, Veracruz, Mexico.
• Martínez AJ; Instituto de Neuroetología, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s/n, Industrial Ánimas, Xalapa 91193, Veracruz, Mexico.
• Cruz-Huerta E; Centro de Investigación y Desarrollo en Alimentos, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s/n, Industrial Ánimas, Xalapa-Enríquez 91193, Veracruz, Mexico.

BACKGROUND/OBJECTIVE

Obesity, clinically defined as a body mass index (BMI) of 30 kg/m2 or higher, is a medical condition characterized by the excessive accumulation of body fat, which can lead to adverse health consequences. As a global public health issue with an escalating prevalence, controlling appetite and satiety is essential for regulating energy balance and managing body weight. Dietary proteins and peptides have gained interest in their potential to prevent and treat obesity by modulating satiety signals. This narrative review analyzes scientific evidence highlighting the role of dietary proteins and peptides in regulating satiety signals and investigates their therapeutic potential in preventing and treating obesity.

METHODS

A comprehensive literature search was conducted in multiple electronic databases, including PubMed, Scopus, and Web of Science. The search focused on articles examining the impact of dietary proteins and peptides on satiety and obesity, encompassing both preclinical and clinical trials.

RESULTS

Several studies have demonstrated a correlation between the intake of specific proteins or peptides from plant and animal sources and satiety regulation. These investigations identified mechanisms where amino acids and peptides interact with enteroendocrine cell receptors, activating intracellular signaling cascades that promote the release of anorexigenic gut hormones such as cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), and peptide YY (PYY). Both in vitro and in vivo assays have shown that these interactions contribute to appetite regulation and the sensation of satiety.

CONCLUSIONS

Using proteins and peptides in the diet may be an effective strategy for regulating appetite and controlling body weight. However, more research-including clinical trials-is needed to understand the underlying mechanisms better and optimize the application of these bioactive compounds in preventing and treating obesity.

Subject(s)

Keywords

Texte intégral: 1 Base de données: MEDLINE Sujet principal: Peptides / Satiété / Protéines alimentaires / Agents antiobésité / Obésité Type d'étude: Literature_review / Risk_factors_studies Limites: Animals / Humans Langue: En Journal: Nutrients Année: 2024 Type de document: Article Pays d'affiliation: Mexique Pays de publication: Suisse