Product Code: BM-2-4-083
CAS number: 40077-57-4
Molecular formula: C147H238N44O42S
Molecular weight: 3325.8
EINECS number: 200-001-8
MDL No.: MFCD00167535
Hs code: /
MDL No.: MFCD00133104
Hs code: 3504009000
Analysis items: HPLC>99.0%, LC-MS
Main market: USA, Australia, Brazil, Japan, Germany, Indonesia, UK, New Zealand , Canada etc.
Manufacturer: BLOOM TECH Changzhou Factory
Technology service: R&D Dept.-4
Usage: Pure API(Active pharmaceutical ingredient) for science research only
Shipping: Shipping as another no sensitive chemical compound name
Aviptadil is a drug with the chemical name N-[2-(aminoethyl)-1-methylethyl]-N-(2-chloroethyl) urea acetate. It is a type of vasodilator and is a pure white or almost white powder. Molecular formula C147H238N44O42S, CAS 40077-57-4. It has low solubility in water, but can dissolve well in organic solvents such as methanol and ethanol. In addition, its solubility in hot water is higher than that in cold water. It has a certain degree of conductivity due to the presence of ionizable groups in its molecular structure. It does not have a special odor, but its solution may have a special odor due to additives or other components. Generally speaking, due to the presence of multiple polar groups in the structure of atepidil acetate, it may undergo phase transition or sublimation at certain temperatures and pressures. It is mainly used in cosmetics, soap, perfume and other products to bring pleasant fragrance to the products.
Chemical Formula C147H238N44O42S
Exact Mass 3324
Molecular Weight 3326
m/z 3325 (100.0%), 3324 (62.9%), 3326 (52.1%), 3327 (41.3%), 3326 (26.9%), 3326 (15.1%), 3325 (9.5%), 3328 (9.4%), 3327 (8.6%), 3327 (7.9%), 3328 (6.7%), 3326 (5.4%), 3328 (5.4%), 3327 (4.7%), 3327 (4.5%), 3328 (4.5%), 3329 (3.6%), 3329 (3.1%), 3326 (2.8%), 3326 (2.7%), 3328 (2.4%), 3328 (2.3%), 3327 (2.2%), 3329 (1.9%), 3325 (1.7%), 3326 (1.6%), 3329 (1.5%), 3329 (1.5%), 3328 (1.3%), 3328 (1.3%), 3328 (1.2%), 3329 (1.1%), 3327 (1.1%), 3326 (1.1%), 3325 (1.0%)
Elemental Analysis C, 53.09; H, 7.21; N, 18.53; O, 20.20; S, 0.96
Aviptadil has many other uses besides being used as a component of spice and essence.
The mechanism of action of acetic acid dipeptidyl in anti-tumor treatment is mainly related to its inhibitory effect on phosphatidylinositol 3-kinase (PI3K). PI3K is a key enzyme involved in cellular signaling, and its abnormal activation is closely related to the occurrence and development of various tumors. Adipidil acetate, as a small molecule inhibitor of PI3K, exhibits high selectivity and affinity towards the alpha subtype of PI3K.
By inhibiting the activity of PI3K, acetic acid dipeptidyl can block the transmission of downstream signaling pathways, thereby inhibiting the proliferation, migration, and invasion of tumor cells. This mechanism of action makes it possible to show potential therapeutic value in breast cancer, head and neck cancer, endometrial cancer and other tumor types.
Specifically, acetic acid dipeptidyl reduces the activation of the PI3K/Akt/mTOR signaling pathway by inhibiting the activity of PI3K. This signaling pathway plays a crucial role in the growth, survival, and invasion of tumor cells. By inhibiting this signaling pathway, acetic acid dipeptidyl can suppress the proliferation and invasion ability of tumor cells, thereby slowing down the growth and spread of tumors.
In addition to its anti-tumor effect, acetic acid dipeptidyl also has a strong vasodilation effect and can be used to treat various lung diseases. Its vasodilatory effect is mainly achieved by inducing pulmonary vasodilation, inhibiting the proliferation of vascular smooth muscle cells (SMCs), and reducing platelet aggregation.
Adipidil acetate can simulate the vasodilation effect of VIP by activating VIP receptors on vascular smooth muscle cells, promoting the efflux of intracellular calcium ions, thereby reducing the tension of vascular smooth muscle and achieving vasodilation. This mechanism of action has shown potential application value in the treatment of diseases such as pulmonary fibrosis, pulmonary arterial hypertension (PAH), and respiratory failure caused by SARS-CoV-2 with acetic acid dipeptidyl.
In the treatment of pulmonary fibrosis, acetic acid dipeptidyl can improve the hemodynamics of pulmonary blood vessels, reduce the degree of scarring and fibrosis of lung tissue, and alleviate the symptoms of patients through its vasodilatory effect. In the treatment of PAH, acetic acid dipeptidyl dilates pulmonary blood vessels, reduces pulmonary artery pressure, and improves patients' respiratory function and exercise tolerance. In the treatment of respiratory failure caused by SARS-CoV-2, acetanilide may alleviate lung inflammation and damage, and improve patients' respiratory function through its anti-inflammatory and antioxidant effects.
Adipidil acetate not only has the value of being used alone in anti-tumor therapy, but can also be combined with other anti-tumor drugs to produce synergistic effects and improve treatment efficacy. This combination therapy strategy provides new ideas and methods for cancer treatment.
Adipidil acetate can be used in combination with traditional chemotherapy drugs to enhance the efficacy of chemotherapy drugs by inhibiting the proliferation and invasion ability of tumor cells. For example, in the treatment of breast cancer, opipidil acetate can be used in combination with chemotherapy drugs such as fluoxetine to significantly extend the progression free survival (PFS) of patients. This synergistic effect may be achieved by inhibiting the PI3K/Akt/mTOR signaling pathway and reducing chemotherapy drug resistance.
Adipidil acetate can also be used in combination with targeted drugs to achieve synergistic therapeutic effects by acting on different signaling pathways and targets. For example, in the treatment of head and neck cancer, acetic acid dipeptidyl can be used in combination with targeted drugs such as EGFR inhibitors to improve treatment efficacy by inhibiting the growth and invasion ability of tumor cells. This synergistic effect may be achieved by inhibiting the cross-talk between the PI3K/Akt/mTOR signaling pathway and the EGFR signaling pathway.
In recent years, immunotherapy has made significant progress in tumor treatment. Adipidil acetate can also be used in combination with immunotherapy drugs to improve treatment efficacy by regulating the tumor microenvironment and enhancing the activity of immune cells. For example, in the treatment of endometrial cancer, acetate dipeptidyl can be used in combination with immunotherapy drugs such as PD-1 inhibitors to improve treatment efficacy by inhibiting tumor cell immune escape and enhancing immune cell killing ability. This synergistic effect may be achieved by inhibiting the PI3K/Akt/mTOR signaling pathway and regulating the activity and function of immune cells.
The process of using acylation reaction to react salicylic acid with acetic anhydride to obtain atepidil acetate can be divided into the following steps:
Salicylic acid undergoes acylation reaction with acetic anhydride to produce atepidil acetate. The specific chemical equation is: C 7 H 4 O 3+C 4 H 6 O 2 → C 11 H 12 O 5
Firstly, ensure that all necessary raw materials, reagents, and instruments for the reaction are ready. The required salicylic acid, acetic anhydride, catalyst, and solvent should meet the chemical purity standards. Prepare appropriate reaction containers to ensure they are clean and dry.
Dissolve salicylic acid and acetic anhydride in appropriate solvents. Usually, anhydrous ethanol or ether can be chosen as solvents, which help promote the progress of the reaction. Mix the dissolved salicylic acid and acetic anhydride solutions together, ensuring that the two solutions are thoroughly mixed.
Add an appropriate amount of catalyst to the mixed solution to promote the acylation reaction. Common catalysts include concentrated sulfuric acid, phosphoric acid, or hydrogen chloride. Select an appropriate amount o
