Product Name: Acetyl Hexapeptide-39 (Silusyne)
Cas No: 1382088-38-1
Purity: 95%
Storage: Keep in dark and cool dry place -5~8 degree Celsius
Sequence: Ac-Ser-Ile-Tyr-Val-Ala-Thr-NH2
Molar Mass: 693.8
Chemical Formula: C32H51N7O10
IUPAC Name: (2S,3S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-3-methylpentanamide
SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N)NC(=O)[C@H](CO)NC(=O)C
InChIKey: RRJXAEMYPWQZHK-SUJJXFDXSA-N
InChI: InChI=1S/C32H51N7O10/c1-8-16(4)25(38-30(47)23(14-40)35-19(7)42)32(49)36-22(13-20-9-11-21(43)12-10-20)29(46)37-24(15(2)3)31(48)34-17(5)28(45)39-26(18(6)41)27(33)44/h9-12,15-18,22-26,40-41,43H,8,13-14H2,1-7H3,(H2,33,44)(H,34,48)(H,35,42)(H,36,49)(H,37,46)(H,38,47)(H,39,45)/t16-,17-,18+,22-,23-,24-,25-,26-/m0/s1
Acetyl Hexapeptide-39 (Silusyne) is a biomimetic peptide specifically engineered to support body-contouring and anti-cellulite cosmetic applications. By targeting key pathways involved in lipid accumulation, Silusyne helps reduce the appearance of uneven texture while promoting a smoother, more refined skin surface. It is widely used in research exploring improved firmness, enhanced microcirculation, and visible contour definition. With excellent stability and compatibility in gels, emulsions, and slimming treatments, Acetyl Hexapeptide-39 is ideal for formulations aimed at promoting a more toned, sculpted, and resilient-looking appearance across targeted body areas.
Acetyl Hexapeptide-39, marketed as Silusyne, is a synthetic slimming and anti-cellulite peptide designed to reduce subcutaneous fat accumulation and smooth the appearance of cellulite. It is a six–amino acid sequence (Ac-Ser-Ile-Tyr-Val-Ala-Thr-NH2) formulated in a dedicated delivery system to target the dermo–hypodermal junction, the interface between skin and underlying fat where cellulite becomes visible.
In cosmetic applications, Silusyne is positioned as a body-contouring peptide for thighs, buttocks, abdomen, and sometimes lower face, aiming to reduce the look of orange peel texture, dimpling, and localized volume.
The core science behind Acetyl Hexapeptide-39 centers on adipocyte differentiation and lipid storage.
Silusyne acts on PGC-1α (Peroxisome proliferator-activated receptor γ coactivator-1α), a transcriptional coactivator that partners with PPARγ to drive adipocyte differentiation and maturation. High PGC-1α activity supports the formation of new fat cells and their capacity to store lipids, contributing to cellulite and localized fat.
In preadipocyte models, Acetyl Hexapeptide-39 has been shown to:
By lowering the number and maturity of fat cells in the treated area, the peptide helps limit new fat storage rather than simply draining existing fat.
Cellulite becomes visible when the dermo–hypodermal junction line (the boundary between dermis and fat lobules) becomes irregular and pulled downward by fibrous septa while fat pushes upward. Technical data for Silusyne show that by reducing adipocyte differentiation and lipid build-up, the junction line becomes less irregular and shorter, leading to a visually smoother surface and less pronounced dimpling.
Some sources also highlight a secondary firming/anti-wrinkle angle, linking improved fat distribution and dermal support to better contours on areas like the lower face or body skin that has lost volume with age.
Within the peptide landscape, Acetyl Hexapeptide-39 belongs to the slimming / anti-cellulite matrix peptides:
This mechanism fits well with current body-care research that looks at cellulite as a structural and biological problem: altered adipogenesis, microcirculation, fibrous septa tension, and dermal thinning all contribute. A PGC-1α-modulating peptide gives a clear, biologically grounded story for long-term use in contouring products.
Silusyne often appears alongside caffeine, carnitine, botanical extracts, or massage-friendly textures in slimming creams, sculpting gels, and anti-cellulite concentrates.
Most data for Acetyl Hexapeptide-39 are from manufacturer and distributor studies, but they are relatively detailed and consistent.
In cultured human preadipocytes, 0.1 mg/mL Acetyl Hexapeptide-39 reduced PGC-1α expression by about 36% after 10 days.
In the same setup, lipid accumulation in treated cells progressed around 37.5% more slowly compared with a control group treated with 200 ppm caffeine, a common slimming standard.
These findings support the claim that Silusyne reduces adipogenesis and slows fat storage in developing adipocytes.
In a small human study:
20 women aged 25–45 applied a cream containing 10 ppm Acetyl Hexapeptide-39 on one thigh, twice daily, for three weeks, while the opposite thigh received a placebo formulation.
Instrumental and imaging analysis showed an average ~11% reduction in cellulite on the treated thigh versus placebo, along with a significant shortening of the dermo–hypodermal junction line, indicating a smoother interface between skin and underlying fat.
While small and manufacturer-driven, these results align with the in vitro mechanism and provide a credible cosmetic-grade evidence base.
Acetyl Hexapeptide-39 is a synthetic, high-purity hexapeptide typically used at very low levels in leave-on body products. Supplier data describe:
Standard irritation and sensitization testing indicates a tolerability profile comparable to other cosmetic peptides at recommended use levels. As always, its role is purely cosmetic, addressing the appearance of cellulite, localized volume, and body contours.
