Sequence: [Cys23-Cys32] Glu-Ile-Gly-Asp-Glu-Glu-Asn-Ser-Ala-Lys-Phe-Pro-Ile-Gly-Arg-Arg-Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Gln-Val
Synonym: Neuropeptide EI-Gly-Arg-Arg-MCH, human, mouse, rat
Molecular Weight: 4186.86
Molecular Formula: C 1 8 2 H 2 8 2 N 5 4 O 5 2 S 4
* Refer to Certificate of Analysis for lot specific data (including water content).
Neuropeptide EI-Gly-Arg-Arg-MCH human, mouse, rat, has been shown to be more potent in stimulating feeding in rats than MCH following intracerebroventricular administration although it did not exhibit better agonist activity in in vitro assays. Its enhanced activity in feeding behaviour compared to MCH might be due to its reduced susceptibility to proteolytic degradation by MCH-degrading enzymes such as endopeptidase 24.11 and aminopeptidase M. [Viale, A; et al., J. Biol. Chem., 274, 6536, (1999)]; [Maulon-Feraille, L; et al., J. Pharmacol. Exp. Ther., 302, 766, (2002)].
M.W.: 4186.86
