Helen Frankenthaler Foundation

MSHa supplier; Melanocortin receptor agonist

alpha-MSH | Melanocortin (MC) Receptors

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α-MSH

Cat. No. 2584

Description

Endogenous melanocortin receptor agonist

Alternative Names

α-Melanotropin, α-Melanocyte-stimulating hormone

Purity

≥95% (HPLC)

Biological Activity for α-MSH

α-MSH is an endogenous melanocortin receptor agonist (K i values are 0.12, 31, 660 and 5700 nM for MC 1, MC 3, MC 4 and MC 5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

Technical Data for α-MSH

PropertyValue
M. Wt1664.9
FormulaC 77 H 109 N 21 O 19 S
SequenceSYSMEHFRWGKPV (Modifications: Ser-1 = N-terminal Ac, Val-13 = C-terminal amide)
StorageStore at -20°C
Purity≥95% (HPLC)
CAS Number581-05-5
PubChem ID16132144
InChI KeyWHNFPRLDDSXQCL-UAZQEYIDSA-N
SmilesCSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility Data for α-MSH

Solubility: Soluble to 0.60 mg/ml in water

References for α-MSH

References are publications that support the biological activity of the product.

  • Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295 PMID:10443584
  • Mizusawa et al (2002) Alpha-melanocyte stimulating hormone and oxyt. induced penile erections, and intracavernous pressure increases in the rat. J.Urol. 167 757 PMID:11792967
  • Yamaoka-Tojo et al (2006) Central neurotranspeptide, alpha-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure. Intern.Med. 45 429 PMID:16679696
2 Citations for α-MSH

Citations are publications that use this product.