The neurokinin 1 (NK 1) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK 2 and NK 3 receptors. The NK 1 receptor is localized in high concentrations in the CNS (particularly the striatum and amygdala) and peripheral tissues.
The neurokinin 1 (NK 1) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK 2 and NK 3 receptors. The NK 1 receptor is localized in high concentrations in the CNS (particularly the striatum, amygdala and some hypothalamic and thalamic nuclei) and peripheral tissues.
NK 1 receptors are thought to mediate central stress reactions, mood control, excitatory neurotransmission, immune modulation and airway and lung function. The receptor displays greater potency for the endogenous agonist substance P than Neurokinin A and Neurokinin B (SP > NKA > NKB). The human gene encoding the NK 1 receptor has been localized on chromosome 2 (2p13.1-p12).
Tocris offers the following scientific literature for NK 1 Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
