Rat endocrine research peptide

Abstract

The effect of rat atrial natriuretic peptide (99-126) (rANP) on cyclic guanosine 3',5'-monophosphate production was investigated in two brain areas, the subfornical organ and the choroid plexus. rANP activated guanylate cyclase in crude homogenates of rat subfornical organ and choroid plexus in concentration and time dependent fashions. A 2-fold stimulation of the enzyme was obtained with 100 nM rANP and a half-maximal stimulation with a 10 nM dose. Our results further support the hypothesis that cGMP mediates the central action of ANP through the activation of specific receptors in localized target sites such as the subfornical organ and choroid plexus.

Author Information

Authors

• Israel A
• Garrido MR
• Barbella Y
• Becemberg I

Affiliations

Faculty of Pharmacy, Universidad Central de Venezuela, Caracas.

Journal Details

Brain Research Bulletin, 01 Feb 1988, 20(2):253-256

PMID: 2897234

References

• Central administration of atrial natriuretic factor inhibits saline preference in the rat. Antunes-Rodrigues J, McCann SM, Samson WK. Endocrinology, (4):1726-1728 1986. PMID: 2936598
• Effects of cholinergic agents on rat liver plasma membrane guanylate cyclase. Lippo de Becemberg I, Herrera V, Perez Ayuso E, Alfonzo M. FEBS Lett, (2):303-306 1982. PMID: 6120856
• Radioautographic localization of 125I-atrial natriuretic factor binding sites in the brain. Bianchi C, Gutkowska J, Ballak M, Thibault G, Garcia R, Genest J, Cantin M. Neuroendocrinology, (3):365-372 1986. PMID: 2949159
• The heart and the atrial natriuretic factor. Cantin M, Genest J. Endocr Rev, (2):107-127 1985. PMID: 2988929
• Title not supplied. Davson. 1967.
• Diuresis and reduction of salt appetite by lateral ventricular infusions of atriopeptin II. Fitts DA, Thunhorst RL, Simpson JB. Brain Res, (1):118-124 1985. PMID: 2933124
• Distribution of [125I]angiotensin II binding sites in the rat brain: a quantitative autoradiographic study. Gehlert DR, Speth RC, Wamsley JK. Neuroscience, (4):837-856 1986. PMID: 3762929
• Quantitative determination of angiotensin II binding sites in rat brain and pituitary gland by autoradiography. Israel A, Correa FM, Niwa M, Saavedra JM. Brain Res, (2):341-345 1984. PMID: 6509323
• Quantitative autoradiographic characterization of receptors for angiotensin II and other neuropeptides in individual brain nuclei and peripheral tissues from single rats. Israel A, Plunkett LM, Saavedra JM. Cell Mol Neurobiol, (3):211-222 1985. PMID: 2998623
• Diuretic and natriuretic action of rat atrial natriuretic peptide (6-33) administered intracerebroventricularly in rats. Israel A, Barbella Y. Brain Res Bull, (2):141-144 1986. PMID: 2945621

Similar Articles

• Effect of water deprivation and salt loading on atrial natriuretic peptide-stimulated guanylate cyclase activity in the rat subfornical organ. Israel A, del Rosario Garrido M, Barbella Y, Becemberg I. Neuroendocrinology, 50(3):334-337, 01 Sep 1989. PMID: 2571954
• C-type natriuretic peptide-22 differentiates between natriuretic peptide receptors in rat choroid plexus and subfornical organ. Himeno A, Niwa M, Nakao K, Suga S, Yamashita K, Kataoka Y, Nakane Y, Imura H, Taniyama K. Eur J Pharmacol, 215(2-3):337-340, 01 May 1992. PMID: 1397001
• Brain natriuretic peptide stimulates particulate guanylate cyclase activity in selected areas of the rat brain. Israel A, Garrido MR, Mathison Y, Barbella Y, Becemberg I. Neurosci Lett, 114(1):107-112, 01 Jun 1990. PMID: 1974338
• Atrial natriuretic peptide (6-33) binding sites: decreased number and affinity in the subfornical organ of spontaneously hypertensive rats. Saavedra JM. J Hypertens Suppl, 4(3):S313-6, 01 Oct 1986. PMID: 3023588